Blood Coagulation, Fibrinolysis and Cellular Haemostasis Introduction
نویسندگان
چکیده
A high plasma concentration of coagulation factor VIII (FVIII) is an important risk factor for venous thromboembolism (VTE) (1-4). In the Leiden Thrombophilia study for example, FVIII levels above 1500 IU/L conferred an almost 5-fold risk for a first episode of deep-vein thrombosis (1). Most importantly, high FVIII is also associated with a very high risk of recurrent venous thromboembolism (4, 5). High factor VIII levels persist over time (3, 5) and are not attributable to an acute phase reaction (2-6). The pathomechanism(s) by which high levels of FVIII lead to an increased risk of venous thrombosis are still unknown. The effect of ß-receptor blockade on factor VIII levels and thrombin generation in patients with venous thromboembolism
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